Source: http://moviesblog.mtv.com/2013/03/13/clone-wars-canceled-star-wars-on-tv/
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Wednesday, March 13, 2013
'Clone Wars' Canceled: What's Next For 'Star Wars' On TV?
A day after the sad, sad news that Lucasfilm had decided to cancel "Star Wars: The Clone Wars," fans of the series are left with lots and lots of questions about what's going on and what it means for the future of "Star Wars" on TV. After thinking over the news for a day, we [...]
ESRB Issues Changes for Marketing of Mature Games ? GamingBolt ...
The ESRB has issues a new bevy of changes for the marketing of games rated ?M? for Mature. Some of these allow for more open marketing of an M-rated game, including cutting trailers or videos for general audiences and no longer requiring an age-gate when viewing said videos online.
Of course, these same trailers must be sent to the ESRB for pre-approval. Also, when cross selling products aka bundling an exclusive demo for a game with another, an M-rated game may be bundled with a lesser-rated game but only after explicit approval from the ESRB. This is to insure that games being cross-sold ?have the same intended audience?.
Finally, with Mature demos, a four second warning regarding the game?s content matter is no longer needed. Instead, the rating must be prominently featured on the demo?s download page. Also, ratings from other organizations cannot be displayed side-by-side with ESRB ratings (this includes Europe?s PEGI system).
Thoughts on the changes?
Source: GiantBomb
Source: http://gamingbolt.com/esrb-issues-changes-for-marketing-of-mature-games
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Tuesday, March 12, 2013
Will Smith Still Has It, Sings 'Fresh Prince' Theme
Will Smith surprised a bunch of students in England with an impromptu performance of the song that made him a star. He's still got it. Also, find out what "Monsters University" has to offer you in today's Dailies! » Every suit Robert De Niro wore in "Casino" [reddit] » John Malkovich will play Blackbeard in [...]
Source: http://moviesblog.mtv.com/2013/03/11/will-smith-fresh-prince/
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Monday, March 11, 2013
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Therapies for ALL and AML targeting MER receptor hold promise of more effect with less side-effect
Therapies for ALL and AML targeting MER receptor hold promise of more effect with less side-effect
Monday, March 11, 2013Two University of Colorado Cancer Center studies show that the protein receptor Mer is overexpressed in many leukemias, and that inhibition of this Mer receptor results in the death of leukemia cells ? without affecting surrounding, healthy cells.
The first study, published today in the journal Oncogene, worked with acute myeloid leukemia (AML), for which current chemotherapies offer a cure rate of only about 55 percent.
"In about 2/3 of all AML patients and about 90 percent of adult AML patients, we found that the Mer receptor was upregulated. Mer receptor protein shouldn't exist in normal myeloid cells, but we found it abnormally expressed," says Doug Graham, MD, PhD, investigator at the CU Cancer Center and associate professor of pediatrics and immunology at the University of Colorado School of Medicine.
The Mer receptor sits within the cell membrane, and when it becomes activated the cell receives signals to grow and survive. Leukemia and perhaps many solid cancers have taken advantage of Mer's cell survival function to assist the cancer's rampant proliferation. When Graham and colleagues used shRNA to silence the production of Mer in leukemia cells, they showed decreased leukemia cell survival, increased sensitivity to existing chemotherapies and longer survival in mouse models of leukemia.
A second study, published this month in Blood Cancer Journal, shows similar results with acute lymphoblastic leukemia (ALL), the most common pediatric cancer.
"The ALL cure rate is already over 80 percent, but for patients who relapse, the prognosis is much less optimistic. We need targeted therapies to use as second-line treatments for the population for whom existing therapies aren't lasting, particularly in patients with relapsed T cell ALL," Graham says.
Second, he points out that a quarter of pediatric ALL patients who respond to existing chemotherapies do so at the price of significant long-term side-effects. "And so in addition to increased survival, the second goal of targeted therapies is decreased side-effects," Graham says.
Inhibition of the Mer protein receptor is promising on both accounts.
"Not only do B-cell and T-cell leukemia cells die when you knock down Mer receptor expression, but these cells are also much more sensitive to existing chemotherapies. By hitting Mer, we're making the chemotherapy more effective," Graham says.
In ALL and AML, Graham's studies show that making Mer inhibition means that less chemotherapy may have equal or stronger effect. Strong preliminary evidence shows that Mer may be the key to less toxic, more effective therapies for leukemia.
###
University of Colorado Denver: http://www.ucdenver.edu
Thanks to University of Colorado Denver for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Security threats, fractures plague US and Afghans
U.S. Secretary of Defense Chuck Hagel, left, meets with Afghanistan's Interior Minister Ghulam Mujtaba Patang at the ISAF (International Security Assistance Force) headquarters in Kabul, Sunday, March 10, 2013. It is Hagel's first official trip since being sworn-in as Obama's Defense Secretary. (AP Photo/Jason Reed, Pool)
U.S. Secretary of Defense Chuck Hagel, left, meets with Afghanistan's Interior Minister Ghulam Mujtaba Patang at the ISAF (International Security Assistance Force) headquarters in Kabul, Sunday, March 10, 2013. It is Hagel's first official trip since being sworn-in as Obama's Defense Secretary. (AP Photo/Jason Reed, Pool)
U.S. Secretary of Defense Chuck Hagel, second left, walks with Afghan Brig. Gen. Aminullah Patyani, left, commander of the Kabul Military Training Center, upon his arrival at the facility in Kabul, Afghanistan, Sunday, March 10, 2013. Hagel is on his first trip to Afghanistan as defense secretary. (AP Photo/Jason Reed, Pool)
U.S. Secretary of Defense Chuck Hagel, center, talks with members of the U.S. Army and Marines during his visit to the Kabul Military Training Center in Kabul, Afghanistan, Sunday, March 10, 2013. Hagel is on his first trip to Afghanistan as defense secretary. (AP Photo/Jason Reed, Pool)
U.S. Secretary of Defense Chuck Hagel, left, is greeted by members of the U.S. Army and Marines during his visit to the Kabul Military Training Center in Kabul, Afghanistan, Sunday, March 10, 2013. Hagel is on his first trip to Afghanistan as defense secretary. (AP Photo/Jason Reed, Pool)
U.S. Secretary of Defense Chuck Hagel, center left, shakes hands with a female Afghan non-commissioned officer under training, during his visit to the Kabul Military Training Center in Kabul, Afghanistan, Sunday, March 10, 2013. Hagel is on his first trip to Afghanistan as defense secretary. (AP Photo/Jason Reed, Pool)
KABUL, Afghanistan (AP) ? A series of security problems and difficult fractures in relations with Afghan leaders plagued Defense Secretary Chuck Hagel's first trip here as Pentagon chief, including the Afghan president's accusations that the U.S. and the Taliban are working in concert to show that violence in the country will worsen if most coalition troops leave.
The top U.S. commander in Afghanistan, Gen. Joseph Dunford, quickly rejected the charges President Hamid Karzai made Sunday as "categorically false." But the accusations were just the latest in a series of disputes that have frayed relations between the two nations as the U.S. works to wind down the war and turn the country's security over to the Afghans.
Speaking to reporters shortly after Karzai made the comments, Dunford said the Afghan leader has never expressed such views to him but said it was understandable that tensions would arise as the coalition balances the need to complete its mission with the Afghans' move to exercise more sovereignty.
"We have fought too hard over the past 12 years, we have shed too much blood over the past 12 years, we have done too much to help the Afghan security forces grow over the last 12 years to ever think that violence or instability would be to our advantage," said Dunford.
Dunford's comments came, however, soon after U.S. officials cancelled a news conference with Hagel and Karzai because of a security threat ? just a day after a suicide bomber on a bicycle struck outside the Afghan Defense Ministry, killing nine Afghan civilians and wounding 14 others. Hagel heard the explosion from the safe location where he was meeting with Afghan officials but was never in danger.
The security problems compounded a series of flare-ups in recent weeks, including a dispute that has stalled the transfer of a U.S. prison to Afghan authority as well as Karzai's order to expel U.S. special operations forces out of Wardak province, which lies just outside the capital, because of allegations that Afghans working with the commandos were involved in abusive behavior.
Hagel and Karzai still planned to meet privately Sunday, and some of the ongoing issues were likely to come up. The U.S. and Afghan leaders are in the midst of negotiations over the long-term presence of American forces in Afghanistan beyond the end of 2014, when all combat troops are scheduled to leave.
U.S. officials would not provide details on the security concerns that led to cancelling the news conference. They spoke on condition of anonymity because they weren't authorized to discuss the matter publicly. But Pentagon press secretary George Little said the cancellation was not due to Karzai's earlier comments about the U.S. and the Taliban.
During a nationally televised speech, Karzai said two suicide bombings that killed 19 people on Saturday ? the one outside the Afghan Defense Ministry and the other near a police checkpoint in eastern Khost province ? show the insurgent group is conducting attacks to help show that international forces will still be needed to keep the peace after their current combat mission ends in 2014.
"The explosions in Kabul and Khost yesterday showed that they are at the service of America and at the service of this phrase: 2014. They are trying to frighten us into thinking that if the foreigners are not in Afghanistan, we would be facing these sorts of incidents," he said during the speech about the state of Afghan women.
Karzai is known for making incendiary comments in his public speeches. And Dunford on Sunday said that some of the recent disputes between the U.S.-led coalition and Afghan leaders "strike at the heart of sovereignty" and could be more political in nature. He said Karzai may be doing what he needs to do to communicate with the Afghan people and their political leaders outside the government.
Dunford also rejected the suggestion that the recent friction reflects an erosion in the U.S. relationship with Afghanistan.
"We do not have a broken relationship, we do not have a lack of trust," said Dunford, adding that none of the political dust-ups have bled over into his dealings with his Afghan security force counterparts. He said efforts to train and advise the Afghan security forces have continued and that plans for them to be in the lead for security across the country later this summer are on track.
Dunford would not detail why the scheduled transfer of the Parwan Detention Center was delayed again and called it a difference in perspective. But he made clear that the U.S. believes it must retain the power to insure that detainees who are deemed to be security threats remain in custody.
Currently, there is an Afghan administrator of the prison, which is located about an hour outside the capital, but the Americans have veto power over the release of detainees. The prisoners held under American authority do not have the right to a trial because the U.S. considers them detainees held as part of an ongoing conflict.
Regarding the move to expel the special operations forces, Dunford said he spoke to Karzai about the issue on Saturday and told him the U.S. is working on a plan to transition security in the Wardak region to Afghan forces. He would not directly say whether the commandos will stay in Wardak when the deadline to leave comes on Monday. But he said Karzai knows they are working on the plan and has not yet issued a directive to the force.
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Associated Press writers Heidi Vogt and Rahim Faiez contributed to this report.
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Follow Lolita C. Baldor on Twitter: http://twitter.com/lbaldor
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